IONSĀ – Ionis Pharmaceuticals, Inc.
Float Short %
6.64
Margin Of Safety %
Put/Call OI Ratio
0.32
EPS Next Q Diff
-1.76
EPS Last/This Y
1.15
EPS This/Next Y
0.21
Price
63.14
Target Price
69.61
Analyst Recom
1.64
Performance Q
77.32
Relative Volume
0.58
Beta
0.26
Ticker: IONS
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| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
|---|---|---|---|---|---|
| 2025-08-15 | IONS | 43.78 | 0.31 | 0.51 | 33723 |
| 2025-08-18 | IONS | 43.43 | 0.29 | 1.02 | 31632 |
| 2025-08-19 | IONS | 42.47 | 0.29 | 0.47 | 32048 |
| 2025-08-20 | IONS | 42.8 | 0.31 | 0.05 | 33906 |
| 2025-08-21 | IONS | 43.24 | 0.30 | 0.14 | 35448 |
| 2025-08-22 | IONS | 42.69 | 0.28 | 0.84 | 38675 |
| 2025-08-25 | IONS | 41.8 | 0.30 | 0.64 | 40175 |
| 2025-08-26 | IONS | 42.24 | 0.31 | 0.08 | 40964 |
| 2025-08-27 | IONS | 42.75 | 0.31 | 0.10 | 40961 |
| 2025-08-28 | IONS | 42.62 | 0.29 | 0.32 | 44305 |
| 2025-08-29 | IONS | 42.65 | 0.29 | 0.32 | 44357 |
| 2025-09-02 | IONS | 58 | 0.29 | 0.25 | 45642 |
| 2025-09-03 | IONS | 60.48 | 0.32 | 0.27 | 53007 |
| 2025-09-04 | IONS | 59.34 | 0.31 | 0.31 | 55827 |
| 2025-09-05 | IONS | 61.24 | 0.32 | 0.10 | 55536 |
| 2025-09-08 | IONS | 60.98 | 0.32 | 0.04 | 55587 |
| 2025-09-09 | IONS | 64.39 | 0.31 | 0.14 | 56178 |
| 2025-09-10 | IONS | 63.97 | 0.31 | 1.60 | 56567 |
| 2025-09-11 | IONS | 64.04 | 0.32 | 0.46 | 56633 |
| 2025-09-12 | IONS | 63.15 | 0.32 | 3.05 | 56706 |
| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
Current Page1 of 1
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| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
|---|---|---|---|---|---|
| 2025-08-15 | IONS | 43.77 | -40.9 | -188.7 | -1.98 |
| 2025-08-18 | IONS | 43.42 | -40.9 | -176.1 | -1.98 |
| 2025-08-19 | IONS | 42.48 | -40.9 | -170.3 | -1.98 |
| 2025-08-20 | IONS | 42.81 | -40.9 | -182.8 | -1.98 |
| 2025-08-21 | IONS | 43.24 | -40.9 | -183.9 | -1.98 |
| 2025-08-22 | IONS | 42.69 | -40.9 | -174.3 | -1.98 |
| 2025-08-25 | IONS | 41.81 | -38.7 | -170.8 | -1.84 |
| 2025-08-26 | IONS | 42.17 | -43.6 | -183.8 | -1.90 |
| 2025-08-27 | IONS | 42.76 | -43.6 | -186.2 | -1.90 |
| 2025-08-28 | IONS | 42.62 | -43.6 | -179.0 | -1.90 |
| 2025-08-29 | IONS | 42.62 | -43.6 | -180.3 | -1.90 |
| 2025-09-02 | IONS | 57.49 | -43.6 | -329.1 | -1.89 |
| 2025-09-03 | IONS | 60.49 | -43.6 | -341.9 | -1.89 |
| 2025-09-04 | IONS | 59.34 | -43.6 | -302.2 | -1.89 |
| 2025-09-05 | IONS | 61.23 | -43.5 | -332.7 | -1.89 |
| 2025-09-08 | IONS | 61.00 | -43.5 | -313.0 | -1.89 |
| 2025-09-09 | IONS | 64.38 | -43.5 | -345.9 | -1.89 |
| 2025-09-10 | IONS | 63.96 | -43.5 | -311.3 | -1.89 |
| 2025-09-11 | IONS | 64.04 | -43.5 | -315.4 | -1.89 |
| 2025-09-12 | IONS | 63.14 | -43.5 | -307.3 | -1.89 |
| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
Current Page1 of 1
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| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
|---|---|---|---|---|
| 2025-08-15 | IONS | -0.57 | 4.88 | 7.45 |
| 2025-08-18 | IONS | -0.57 | 3.72 | 7.45 |
| 2025-08-19 | IONS | -0.57 | 3.72 | 7.33 |
| 2025-08-20 | IONS | -1.66 | 3.72 | 7.33 |
| 2025-08-21 | IONS | -2.40 | 3.72 | 7.33 |
| 2025-08-22 | IONS | -2.40 | 3.72 | 7.33 |
| 2025-08-25 | IONS | -2.31 | 0.41 | 7.33 |
| 2025-08-26 | IONS | -2.41 | 0.41 | 7.33 |
| 2025-08-27 | IONS | -2.41 | 0.41 | 6.82 |
| 2025-08-28 | IONS | -2.41 | 0.41 | 6.82 |
| 2025-08-29 | IONS | -2.41 | 0.41 | 6.82 |
| 2025-09-02 | IONS | -2.41 | 0.39 | 6.82 |
| 2025-09-03 | IONS | -2.41 | 0.39 | 6.82 |
| 2025-09-04 | IONS | -2.41 | 0.39 | 6.82 |
| 2025-09-05 | IONS | -31.09 | 0.39 | 6.82 |
| 2025-09-08 | IONS | -31.09 | 0.43 | 6.82 |
| 2025-09-09 | IONS | -31.09 | 0.43 | 6.82 |
| 2025-09-10 | IONS | -32.40 | 0.43 | 6.82 |
| 2025-09-11 | IONS | -33.59 | 0.43 | 6.64 |
| 2025-09-12 | IONS | -33.59 | 0.43 | 6.64 |
| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
Current Page1 of 1
Last Quarter Act. EPSā
0.7
Avg. EPS Est. Current Quarter
-1.04
Avg. EPS Est. Next Quarter
-1.06
Insider Transactions
-33.59
Institutional Transactions
0.43
Beta
0.26
Average Sales Estimate Current Quarter
132
Average Sales Estimate Next Quarter
145
Fair Value
Quality Score
42
Growth Score
38
Sentiment Score
88
Actual DrawDown %
2.4
Max Drawdown 5-Year %
-60
Target Price
69.61
P/E
Forward P/E
PEG
P/S
10.66
P/B
15.92
P/Free Cash Flow
EPS
-1.85
Average EPS Est. Cur. Yā
-1.89
EPS Next Y. (Est.)
-1.68
Target Price Estimates Raised
Target Price Estimates Lowered
Profit Margin
-28.36
Relative Volume
0.58
Return on Equity vs Sector %
-67.3
Return on Equity vs Industry %
-54.2
EPS 1 7Days Diff
EPS 1 30Days Diff
0.03
EBIT Estimation
-307.3
Ionis Pharmaceuticals, Inc.Sector: Healthcare
Industry: Biotechnology
Employees: 1069
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
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