IONSĀ – Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc.IONS
$28.40Name : Ionis Pharmaceuticals, Inc.
Sector : Healthcare
Industry: Biotechnology
Mark. Cap: $4,514,605,568.00
EPSttm : -3.04
Ionis Pharmaceuticals, Inc.
$28.40
0.18%$0.05Float Short %
8.63
Margin Of Safety %
Put/Call OI Ratio
0.62
EPS Next Q Diff
-0.14
EPS Last/This Y
0.13
EPS This/Next Y
0.74
Price
28.4
Target Price
55.83
Analyst Recom
1.78
Performance Q
-12.02
Relative Volume
0.47
Beta
0.18
Ticker: IONS
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| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
|---|---|---|---|---|---|
| 2025-03-21 | IONS | 32.9 | 0.70 | 0.09 | 16156 |
| 2025-03-24 | IONS | 33.43 | 0.71 | 0.04 | 15166 |
| 2025-03-25 | IONS | 32.3 | 0.69 | 0.01 | 15364 |
| 2025-03-26 | IONS | 31.52 | 0.67 | 0.03 | 15662 |
| 2025-03-27 | IONS | 31.71 | 0.67 | 0.25 | 15635 |
| 2025-03-28 | IONS | 31.17 | 0.67 | 999.99 | 15643 |
| 2025-03-31 | IONS | 30.16 | 0.67 | 0.21 | 15637 |
| 2025-04-01 | IONS | 27.39 | 0.67 | 0.07 | 15903 |
| 2025-04-02 | IONS | 28.72 | 0.65 | 0.11 | 16320 |
| 2025-04-03 | IONS | 28.5 | 0.64 | 0.02 | 16453 |
| 2025-04-04 | IONS | 27.05 | 0.64 | 3.29 | 16561 |
| 2025-04-07 | IONS | 27.55 | 0.64 | 1.03 | 16576 |
| 2025-04-08 | IONS | 25.54 | 0.63 | 0.10 | 16540 |
| 2025-04-09 | IONS | 27.76 | 0.62 | 0.07 | 16703 |
| 2025-04-10 | IONS | 26.72 | 0.62 | 0.05 | 16632 |
| 2025-04-11 | IONS | 27.92 | 0.59 | 0.17 | 16382 |
| 2025-04-14 | IONS | 28.69 | 0.59 | 0.10 | 16481 |
| 2025-04-15 | IONS | 28.54 | 0.62 | 0.15 | 17324 |
| 2025-04-16 | IONS | 28.36 | 0.62 | 0.23 | 17336 |
| 2025-04-17 | IONS | 28.4 | 0.62 | 2.38 | 17350 |
| 2025-04-18 | IONS | 28.4 | 0.62 | 2.43 | 17350 |
| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
Current Page1 of 1
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| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
|---|---|---|---|---|---|
| 2025-03-21 | IONS | 32.92 | -20.6 | -161.2 | -2.88 |
| 2025-03-24 | IONS | 33.45 | -20.6 | -168.2 | -2.88 |
| 2025-03-25 | IONS | 32.27 | -20.6 | -135.0 | -2.88 |
| 2025-03-26 | IONS | 31.49 | -17.6 | -142.0 | -2.80 |
| 2025-03-27 | IONS | 31.72 | -17.6 | -162.1 | -2.80 |
| 2025-03-28 | IONS | 31.15 | -17.6 | -146.0 | -2.80 |
| 2025-03-31 | IONS | 30.17 | -17.6 | -137.1 | -2.80 |
| 2025-04-01 | IONS | 27.26 | -17.6 | -94.5 | -2.80 |
| 2025-04-02 | IONS | 28.71 | -17.6 | -193.2 | -2.82 |
| 2025-04-03 | IONS | 28.52 | -17.6 | -153.1 | -2.82 |
| 2025-04-04 | IONS | 27.07 | -17.6 | -123.9 | -2.82 |
| 2025-04-07 | IONS | 27.52 | -17.6 | -168.2 | -2.82 |
| 2025-04-08 | IONS | 25.51 | -17.6 | -106.9 | -2.82 |
| 2025-04-09 | IONS | 27.77 | -17.6 | -263.7 | -2.82 |
| 2025-04-10 | IONS | 26.70 | -17.6 | -171.1 | -2.82 |
| 2025-04-11 | IONS | 27.92 | -17.6 | -231.4 | -2.82 |
| 2025-04-14 | IONS | 28.68 | -17.6 | -218.7 | -2.85 |
| 2025-04-15 | IONS | 28.38 | -17.6 | -191.2 | -2.85 |
| 2025-04-16 | IONS | 28.36 | -17.3 | -198.1 | -2.84 |
| 2025-04-17 | IONS | 28.40 | -18.5 | -199.8 | -2.91 |
| 2025-04-18 | IONS | 28.40 | -18.5 | -198.6 | -2.91 |
| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
Current Page1 of 1
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| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
|---|---|---|---|---|
| 2025-03-21 | IONS | -3.87 | 1.15 | 8.31 |
| 2025-03-24 | IONS | -3.87 | 1.13 | 8.31 |
| 2025-03-25 | IONS | -3.87 | 1.13 | 8.31 |
| 2025-03-26 | IONS | -3.87 | 1.13 | 8.29 |
| 2025-03-27 | IONS | -3.87 | 1.13 | 8.29 |
| 2025-03-28 | IONS | -3.87 | 1.13 | 8.29 |
| 2025-03-31 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-01 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-02 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-03 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-04 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-07 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-08 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-09 | IONS | -3.87 | 1.17 | 8.29 |
| 2025-04-10 | IONS | -3.87 | 1.17 | 8.63 |
| 2025-04-11 | IONS | -3.87 | 1.17 | 8.63 |
| 2025-04-14 | IONS | -3.87 | 1.18 | 8.63 |
| 2025-04-15 | IONS | -3.87 | 1.18 | 8.63 |
| 2025-04-16 | IONS | -3.87 | 1.18 | 8.63 |
| 2025-04-17 | IONS | -4.03 | 1.18 | 8.63 |
| 2025-04-18 | IONS | -4.03 | 1.18 | 8.63 |
| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
Current Page1 of 1
Last Quarter Act. EPSā
-0.66
Avg. EPS Est. Current Quarter
-0.9
Avg. EPS Est. Next Quarter
-0.8
Insider Transactions
-4.03
Institutional Transactions
1.18
Beta
0.18
Average Sales Estimate Current Quarter
144
Average Sales Estimate Next Quarter
152
Fair Value
Quality Score
41
Growth Score
37
Sentiment Score
74
Actual DrawDown %
55.9
Max Drawdown 5-Year %
-60
Target Price
55.83
P/E
Forward P/E
PEG
P/S
6.4
P/B
7.62
P/Free Cash Flow
EPS
-3.04
Average EPS Est. Cur. Yā
-2.91
EPS Next Y. (Est.)
-2.17
Target Price Estimates Raised
Target Price Estimates Lowered
Profit Margin
-64.28
Relative Volume
0.47
Return on Equity vs Sector %
-97.1
Return on Equity vs Industry %
-83.7
EPS 1 7Days Diff
-0.1
EPS 1 30Days Diff
-0.04
EBIT Estimation
-198.6
Ionis Pharmaceuticals, Inc.Sector: Healthcare
Industry: Biotechnology
Employees: 1069
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
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