IONSĀ – Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc.IONS
$43.03Name : Ionis Pharmaceuticals, Inc.
Sector : Healthcare
Industry: Biotechnology
Mark. Cap: $6,858,594,816.00
EPSttm : -1.76
Ionis Pharmaceuticals, Inc.
$43.03
0.12%$0.05Float Short %
8.3
Margin Of Safety %
Put/Call OI Ratio
0.35
EPS Next Q Diff
-1.6
EPS Last/This Y
0.74
EPS This/Next Y
0.39
Price
43.03
Target Price
58.25
Analyst Recom
1.69
Performance Q
35.7
Relative Volume
1.33
Beta
0.25
Ticker: IONS
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| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
|---|---|---|---|---|---|
| 2025-07-04 | IONS | 43.19 | 0.43 | 1.58 | 28474 |
| 2025-07-07 | IONS | 41.78 | 0.43 | 0.89 | 28614 |
| 2025-07-08 | IONS | 41.34 | 0.45 | 0.06 | 29796 |
| 2025-07-09 | IONS | 42.83 | 0.44 | 0.70 | 29911 |
| 2025-07-10 | IONS | 42.34 | 0.45 | 0.21 | 30029 |
| 2025-07-11 | IONS | 41.74 | 0.45 | 0.46 | 30018 |
| 2025-07-14 | IONS | 42.58 | 0.45 | 0.02 | 30056 |
| 2025-07-15 | IONS | 42.01 | 0.44 | 0.00 | 31522 |
| 2025-07-16 | IONS | 42.77 | 0.43 | 0.91 | 31623 |
| 2025-07-17 | IONS | 42.16 | 0.44 | 0.00 | 31680 |
| 2025-07-18 | IONS | 41.75 | 0.44 | 0.43 | 31683 |
| 2025-07-21 | IONS | 41.57 | 0.32 | 0.13 | 24611 |
| 2025-07-22 | IONS | 41.97 | 0.32 | 0.01 | 24649 |
| 2025-07-23 | IONS | 42.37 | 0.32 | 0.12 | 24705 |
| 2025-07-24 | IONS | 42.14 | 0.32 | 0.14 | 24855 |
| 2025-07-25 | IONS | 42.24 | 0.32 | 0.69 | 24873 |
| 2025-07-28 | IONS | 41.21 | 0.32 | 1.63 | 25320 |
| 2025-07-29 | IONS | 41.43 | 0.33 | 4.82 | 25657 |
| 2025-07-30 | IONS | 43.35 | 0.34 | 0.01 | 25830 |
| 2025-07-31 | IONS | 42.99 | 0.33 | 0.77 | 26489 |
| 2025-08-01 | IONS | 43.03 | 0.35 | 0.59 | 27674 |
| Date | Symbol | Last | P/C OI | P/C Vol | Total OI |
Current Page1 of 1
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| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
|---|---|---|---|---|---|
| 2025-07-04 | IONS | 43.00 | 154.8 | -75.5 | -2.29 |
| 2025-07-07 | IONS | 41.78 | 154.8 | -67.8 | -2.29 |
| 2025-07-08 | IONS | 41.34 | 154.8 | -77.1 | -2.29 |
| 2025-07-09 | IONS | 42.83 | 154.8 | -101.2 | -2.29 |
| 2025-07-10 | IONS | 42.38 | 154.8 | -77.1 | -2.29 |
| 2025-07-11 | IONS | 41.73 | 154.8 | -69.3 | -2.29 |
| 2025-07-14 | IONS | 42.55 | 154.8 | -92.7 | -2.29 |
| 2025-07-15 | IONS | 42.00 | 154.8 | -75.9 | -2.29 |
| 2025-07-16 | IONS | 42.78 | 154.8 | -92.1 | -2.29 |
| 2025-07-17 | IONS | 42.17 | 154.8 | -75.3 | -2.29 |
| 2025-07-18 | IONS | 41.76 | 154.8 | -77.5 | -2.29 |
| 2025-07-21 | IONS | 41.55 | 154.8 | -79.9 | -2.29 |
| 2025-07-22 | IONS | 41.95 | 154.8 | -87.6 | -2.29 |
| 2025-07-23 | IONS | 42.38 | 154.8 | -87.8 | -2.29 |
| 2025-07-24 | IONS | 42.15 | 169.1 | -79.7 | -2.29 |
| 2025-07-25 | IONS | 42.24 | 169.1 | -83.7 | -2.30 |
| 2025-07-28 | IONS | 41.33 | 169.1 | -71.2 | -2.30 |
| 2025-07-29 | IONS | 41.48 | 169.1 | -86.4 | -2.30 |
| 2025-07-30 | IONS | 43.37 | 169.1 | -106.2 | -2.30 |
| 2025-07-31 | IONS | 42.98 | -22.4 | -92.8 | -2.30 |
| 2025-08-01 | IONS | 43.03 | -22.4 | -269.8 | -2.30 |
| Date | Ticker | Price | Current Quarter Growth Estimate | EBIT Estimation | Average EPS Estimate Current Year |
Current Page1 of 1
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| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
|---|---|---|---|---|
| 2025-07-04 | IONS | -3.77 | 4.63 | 9.16 |
| 2025-07-07 | IONS | -3.77 | 4.66 | 9.16 |
| 2025-07-08 | IONS | -3.77 | 4.66 | 9.16 |
| 2025-07-09 | IONS | -3.77 | 4.66 | 9.16 |
| 2025-07-10 | IONS | -3.77 | 4.66 | 9.16 |
| 2025-07-11 | IONS | -3.77 | 4.66 | 9.11 |
| 2025-07-14 | IONS | -3.77 | 4.70 | 9.11 |
| 2025-07-15 | IONS | -3.77 | 4.70 | 9.11 |
| 2025-07-16 | IONS | -3.79 | 4.70 | 9.11 |
| 2025-07-17 | IONS | -3.79 | 4.70 | 9.11 |
| 2025-07-18 | IONS | -1.57 | 4.70 | 9.11 |
| 2025-07-21 | IONS | -1.57 | 4.72 | 9.11 |
| 2025-07-22 | IONS | -1.56 | 4.72 | 9.11 |
| 2025-07-23 | IONS | -1.56 | 4.72 | 9.11 |
| 2025-07-24 | IONS | -1.56 | 4.72 | 9.11 |
| 2025-07-25 | IONS | -1.57 | 4.72 | 8.30 |
| 2025-07-28 | IONS | -1.57 | 4.84 | 8.30 |
| 2025-07-29 | IONS | -1.57 | 4.84 | 8.30 |
| 2025-07-30 | IONS | -1.57 | 4.84 | 8.30 |
| 2025-07-31 | IONS | -1.57 | 4.84 | 8.30 |
| 2025-08-01 | IONS | -1.63 | 4.84 | 8.30 |
| Date | Ticker | Insider Transactions | Institutional Transactions | Float Short |
Current Page1 of 1
Last Quarter Act. EPSā
0.7
Avg. EPS Est. Current Quarter
-0.89
Avg. EPS Est. Next Quarter
-0.9
Insider Transactions
-1.63
Institutional Transactions
4.84
Beta
0.25
Average Sales Estimate Current Quarter
155
Average Sales Estimate Next Quarter
169
Fair Value
Quality Score
43
Growth Score
41
Sentiment Score
59
Actual DrawDown %
33.2
Max Drawdown 5-Year %
-60
Target Price
58.25
P/E
Forward P/E
PEG
P/S
7.26
P/B
10.84
P/Free Cash Flow
EPS
-1.85
Average EPS Est. Cur. Yā
-2.3
EPS Next Y. (Est.)
-1.9
Target Price Estimates Raised
2
Target Price Estimates Lowered
Profit Margin
-28.36
Relative Volume
1.33
Return on Equity vs Sector %
-66.2
Return on Equity vs Industry %
-47.5
EPS 1 7Days Diff
EPS 1 30Days Diff
-0.01
EBIT Estimation
-269.8
Ionis Pharmaceuticals, Inc.Sector: Healthcare
Industry: Biotechnology
Employees: 1069
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
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